Year after year, the East-West Shrine Bowl serves as a launchpad for future NFL talent. This year was no different, with a strong group of players hearing their names called during the 2025 NFL Draft:
| First Name | Last Name | College | Round/Pick | NFL Team |
|---|---|---|---|---|
| Malachi | Lawrence | UCF | 1 pick 23 | Dallas Cowboys |
| Jalen | Huskey | Maryland | 3 pick 100 | Jacksonville Jaguars |
| Tyler | Onyedim | Texas A&M | 3 pick 66 | Denver Broncos |
| Albert | Regis | Texas A&M | 3 Pick 81 | Jacksonville Jaguars |
| Zavion | Thomas | LSU | 3 pick 89 | Chicago Bears |
| Eli | Raridon | Notre Dame | 3 pick 95 | New England Patriots |
| Darrell | Jackson Jr | Florida State | 4 pick 103 | NY Jets |
| Kaleb | Proctor | Southeastern Louisiana | 4 pick 104 | Arizona Cardinals |
| Febechi | Nwaiwu | Oklahoma | 4 pick 106 | Houston Texans |
| Jadon | Canady | Oregon | 4 pick 109 | Kansas City Chiefs |
| Cade | Klubnik | Clemson | 4 pick 110 | New York Jets |
| Wesley | Williams | Duke | 4 pick 119 | Jacksonville Jaguars |
| Kaden | Wetjen | Iowa | 4 pick 121 | Pittsburgh Steelers |
| Skyler | Bell | Connecticut | 4 pick 125 | Buffalo Bills |
| Colbie | Young | Georgia | 4 pick 140 | Cincinnati Bengals |
| Dalton | Johnson | Arizona | 5 pick 150 | Las Vegas Raiders |
| Jager | Burton | Kentucky | 5 pick 153 | Green Bay Packers |
| Jaden | Dugger | Louisiana | 5 pick 154 | San Francisco 49ers |
| DeMonte | Capehart | Clemson | 5 pick 155 | Tampa Bay Buccaneers |
| Max | Bredeson | Michigan | 5 pick 159 | Minnesota Vikings |
| Riley | Nowakowski | Indiana | 5 pick 169 | Pittsburgh Steelers |
| Seydou | Traore | Mississippi State | 5 pick 180 | Miami Dolphins |
| Karson | Sharar | Iowa | 6 pick 183 | Arizona Cardinals |
| Jackie | Marshall | Baylor | 6 pick 184 | Tennessee Titans |
| Bauer | Sharp | LSU | 6 pick 185 | Tampa Bay Buccaneers |
| Brian | Parker II | Duke | 6 pick 189 | Cincinnati Bengals |
| Malik | Benson | Oregon | 6 pick 195 | Las Vegas Raiders |
| Demond | Claiborne | Wake Forest | 6 pick 198 | Minnesota Vikings |
| Emmanuel | Henderson Jr | Kansas | 6 Pick 199 | Seattle Seahawks |
| Devon "DJ" | Campbell | Texas | 6 pick 200 | Miami Dolphins |
| Domani | Jackson | Alabama | 6 pick 201 | Green Bay Packers |
| CJ | Williams | Stanford | 6 pick 203 | Jacksonville Jaguars |
| Micah | Morris | Georgia | 6 pick 207 | Philadelphia Eagles |
| Harold | Perkins Jr | LSU | 6 pick 215 | Atlanta Falcons |
| Trey | Smack | Florida | 6 pick 216 | Green Bay Packers |
| Jayden | Williams | Ole Miss | 7 pick 217 | Arizona Cardinals |
| Anthony | Smith | East Carolina | 7 pick 218 | Dallas Cowboys |
| Jack | Endries | Texas | 7 pick 221 | Cincinnati Bengals |
| Robert | Spears-Jennings | Oklahoma | 7 pick 224 | Pittsburgh Steelers |
| Jaren | Kanak | Oklahoma | 7 pick 225 | Tennessee Titans |
| Landon | Robinson | Navy | 7 pick 226 | Cincinnati Bengals |
| Jackson | Kuwatch | Miami (OH) | 7 pick 227 | Carolina Panthers |
| Brandon | Cleveland | NC State | 7 pick 229 | Las Vegas Raiders |
| Eli | Heidenreich | Navy | 7 pick 230 | Pittsburgh Steeler |
| Behren | Morton | Texas Tech | 7 pick 234 | New England Patriots |
| Andre | Fuller | Toledo | 7 pick 236 | Seattle Seahawks |
| Tommy | Doman | Florida | 7 pick 239 | Buffalo Bills |
| Ar'maj | Reed-Adams | Texas A&M | 7 pick 241 | Buffalo Bills |
| Cole | Wisniewski | Texas Tech | 7 pick 244 | Philadelphia Eagles |
| Keyshawn | James-Newby | New Mexico | 7 pick 252 | Philadelphia Eagles |
| Evan | Beerntsen | Northwestern | 7 pick 253 | Baltimore Ravens |
| Dallen | Bentley | Utah | 7 pick 256 | Denver Broncos |
| Red | Murdock | Buffalo | 7 pick 257 | Denver Broncos |
